Either the 25-06 or 270 would work perfectly for mule deer. I would use something like the 120 gr. Nosler Partition or 110 gr. Nosler Accubond in the 25-06 and the 130 gr. Partition or Nosler Accubond in the 270. The one you shoot the best is the one I would take as both are great long range deer calibers. Good luck and you cannot go wrong with either one!