I have a model 70ss winchester 22-250 shooting hornady 50gr vmax. I love it for yotes! IMO the 22-250 is hands down the best varmit caliber ever made! I also have a pre 64 model 70 243 that I like alot and have killed everything from bobcats to deer with. I would go with the 243 if you want to hunt deer with it too. I think the 22-250 is pretty light for deer and also 243 is the minimum caliber thats legal in some states.