My 2 cents: I have a .270 Winchester and have killed every one of my big game with it. A nice Pronghorn Buck, 1 5x5 bull, 1 Raghorn bull, a 6x6 bull (New Mexico), and 4 Mule Deer Bucks, and a lot of Mule Deer and Whitetail does. I had the chance to buy a 300 WSM and a 300 Winchester Mag, but bought another .270 Winchester in the Winchester Model 70 Extreme, with a new Nikon Monarch BDC Scope. I gave my Ruger .270 Winchester to my brother so he can start hunting again. What can I say? I don't reload, but am partial to the .270 Winchester and have killed all of my animals with one. I suppose if I shot a .30-06 Springfield, I would be saying the same thing. It's all about what you're comfortable with and how good you shoot. Know your gun and limitations (or extremes), and you'll be a great rifle hunter.