I guess it would depend on the wolf, if you are talking about a defensive situation I would wait until he got within powder burn distance (literally) and shoot him with the pistol. I think the likelihood of being attacked by a single wolf is pretty remote, the best use of the bow would be in your non gun hand to keep from getting a wolf bite while lining up your killing shot. If you are going to claim self defense against an animal that the bunny huggers love more than their own kids then you should be able to prove it beyond any doubt. If on the other hand you have a wolf tag in your pocket wait for a shot you are comfortable with and take it if you get it. Even a wolf deserves to be killed cleanly!