I have killed antelope with a variety of calibers from .243 to 300 RUM, and had satisfactory performance out of all of them. The RUM with Berger 185 VLD-H was actually a great caliber for antelope due to its resistance to wind drift. Where I hunt antelope, wind is a common companion. It may be surprising, but meat loss with the RUM wasn't bad.
Last year I used a 7-08 with Barnes TTSX, and had a nice clean one shot kill at 340 yards. I really like that cartridge and bullet for antelope. Meat loss was almost non-existant.
I also think 6.5's with their high BCs would be great in the wind.