The .22 is legal but not the 50 grain bullet.
I've used a number of different rifles and calibers but my "designated" rifle is a .25-06.
Your 30-06 using the 180 gr. bullet you are shooting and it is sighted in with will work just fine. It's not a bad excuse to pine for a new rifle though. The 6mm Remington, 257 Roberts, and 25-06 are all excellent antelope rifles if you really want a new rifle.
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Jeremy, I'd use the '06 and use the money you'd spend on an unneeded rifle for the antelope tag & gas for your trip. Not that buying another gun is ever a bad idea, but the truth is that the rifle that you're familiar with is the best choice. Just my take on it.
Thanks for all the advice guys. Still not sure whether I will get a new gun or just stock up on ammo and reloading supplies. I am looking at some 25-06 guns right now though.
They'll all work; just buy whatever interests you most. The 6.5 wasn't on your list but that's what I'd recommend.
Sometimes I feel like I'm the only person that hunts with a 6.5 and I can't figure out why?
If I was buying new, I'd buy a Savage LRH in 6.5x284.
The Wy regs say: "Any center fire firearm of atleast 22 cal and having a bullet weight of atleast 60 grains, or a cartridge that generally delivers atleast 500 foot pounds of impact at 100 yards, and using a lead or expanding point bullet"
Does that mean it has to be 22 cal, 60 grains, and 500 energy? It could be taken to mean anything that has atleast 500 of energy at 100 yards would be legal. A 204 ruger with a 24 gr hornady NTX makes 717 of energy at 100 yards. I have no desire to shoot an antelope with that light of a bullet, just saying
Any center fire firearm of at least 22 cal and
a) having a bullet weight of atleast 60 grains,
b) a cartridge that generally delivers atleast 500 foot pounds of impact at 100 yards,
and using a lead or expanding point bullet